A cuproptosis-related lncRNA signature predicts the prognosis and immune cell status in head and neck squamous cell carcinoma

Introduction The incidence of head and neck squamous cell carcinoma (HNSCC), one the most prevalent tumors, is increasing rapidly worldwide. Cuproptosis, as a new copper-dependent death form, was proposed recently. However, prognosis value immune effects cuproptosis-related lncRNAs (CRLs) have not yet been elucidated in HNSCC. Methods In current study, expression pattern, differential profile, clinical correlation, DNA methylation, functional enrichment, univariate factor, CRLs were analyzed. A four-CRL signature constructed using least absolute shrinkage selection operator (LASSO) algorithm. Results showed that 20 had significant on stage progression Sixteen tightly correlated with overall survival (OS) HNSCC patients. Particularly, lnc-FGF3-4 single risk factor upregulated tissues negatively impacted methylation probes cg02278768 (MIR9-3HG), cg07312099 (ASAH1-AS1), cg16867777 (TIAM1-AS1) also included MAP4K3-DT, lnc-TCEA3-1, MIR9-3HG, CDKN2A-DT significantly negative effect activation T cells follicular helper OS probability Functional analysis revealed cycle, replication, p53 signal pathways enriched. Discussion novel CRL-related has potential prediction Targeting may be promising therapeutic strategy for